• br Disclosures br Acknowledgements This work

  2020-04-09

  

  Disclosures Acknowledgements This work was supported in part by grants from the Ministerio de Ciencia e Innovación, Spain (SAF2010-22051) and Xunta de Galicia, Spain (INCITE08PXIB203092PR). Introduction Ca is a key element in cardiac excitation–contraction (EC) coupling. In each heartbeat,

• At present there have been relatively few

  2020-04-09

  

  At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal lysophosphatidic acid receptor nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relati

• In the past few years DNA templated

  2020-04-09

  

  In the past few years, DNA-templated fluorescent metal nanoparticles have been developed as ideal alternatives to organic dyes due to their facile synthetic process, outstanding optical properties, ultrafine size, and fine biological compatibility. Since the first successful demonstration of DNA-tem

• Henderson et al reported that allergen induced airway remode

  2020-04-09

  

  Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small bronchi was also suppressed by montelukast. The CysLT2 receptor antagonist BayCysLT2RA

• To date methods for the simultaneous analysis of multiple

  2020-04-09

  

  To date, methods for the simultaneous analysis of multiple probe drugs in the plasma have been described by using HPLC-DAD or LC–MS/MS. Although previous cocktail methods have used combinations of those four or other probe drugs with LC–MS/MS methods, most of those studies focused on only the analys

• MNs can be obtained from iPSCs using signaling molecules

  2020-04-08

  

  MNs can be obtained from iPSCs, using signaling molecules such as retinoic GM6001 australia (RA) and Sonic hedgehog (Shh) (Table S1).4, 5, 12, 23, 24, 25, 26, 27, 28, 29 These methods rely on developmental principles and require changing the combinations of signaling molecules at multiple steps, wh

• br Materials and methods br Results

  2020-04-08

  

  Materials and methods Results Discussion Plant U-box E3 Ub ligases regulate diverse plant-specific cellular processes [1], [2], [3], [4]. However, structural and functional relationships between U-box E3s and their E2 partners are largely unknown in higher plants [24], [25]. In this study,

• It was demonstrated that the addition of fold excess of

  2020-04-08

  

  It was demonstrated that the addition of 10-fold excess of α-synuclein without modifications (with respect to the molar concentration of tetrameric GAPDH) leads to partial inactivation of GAPDH after 1-h incubation by 20% (Fig. 4, curve 2) in IOX2 to insignificant decrease of the specific activity

• AMPK is a master regulator of metabolic homeostasis

  2020-04-08

  

  AMPK is a master regulator of metabolic homeostasis, its broad spectrum of metabolic activities makes it an attractive target for treatment of metabolic and related disorders including Diabetes and Obesity (Madhavi et al., 2018). It controls lipid metabolism through its target genes PPAR-γ, C/EBP-α

• The aim of this study was to discover and characterize

  2020-04-08

  

  The aim of this study was to discover and characterize a novel thermostable gluten-specific prolyl endopeptidase suitable for use during the mashing step of beer production. Subsequently to express the recombinant enzyme in E.coli and to demonstrate degradation of immunogenic gluten derived peptides

• br Materials and methods br Results br Discussion In this

  2020-04-08

  

  Materials and methods Results Discussion In this study, we employed a liquid chromatography mass spectrometry (LC–MS)-based metabolomic approach to profile GEF metabolism and bioactivation in human and mouse liver microsomes. Metabolomic approaches rendered us readily screen out the GEF-rel

• Another significant finding in our study was

  2020-04-07

  

  Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in regadenoson (Fig. 11). Because of the consistent protection conferred by CK2 inhibition during OGD, im

• Endothelin appears to have direct

  2020-04-07

  

  Endothelin 1 appears to have direct effects on neoplastic 34450 by inducing cellular proliferation, angiogenesis, migration, invasion, and inhibition of apoptosis [10]. Endothelin 1 mediates mitogenic effects in some epithelial tumors such as colorectal, ovarian, and prostate cancers [11], [12], [1

• The development of C S mutation has

  2020-04-07

  

  The development of C797S mutation has been reported in vivo in a small cohort (15 subjects) of EGFR T790M positive patients progressing after Osimertinib: this tertiary mutation was found, using a droplet digital PCR (ddPCR) assay, in 40% of patients after AR to this agent, while 33% of the cases ex

• Introduction Safety critical systems are

  2020-04-07

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within

15333 records 807/1023 page Previous Next First page 上5页 806807808809810 下5页 Last page