• A fourth question is whether mesenchymal precursors

  2018-10-24

  

  A fourth question is whether mesenchymal precursors in other tissues can cross the mesodermal/neural crest lineage boundary. In this regard, mesenchymal tissues such as bone and adipose tissue are also developmentally generated by both the neural crest and mesoderm, and bone marrow and adipose-deriv

• Effective differentiation of hPSCs into DE is

  2018-10-24

  

  Effective differentiation of hPSCs into DE is coupled with the suppression of E-CADHERIN/CDH1 and pluripotency. Whereas BMP signaling has been reported to suppress E-CADHERIN/CDH1 and pluripotency (Teo et al., 2011, 2012), we observed that WNT3A is not as effective as GSK-3 inhibitors in suppressing

• Y has been reported to permit survival of

  2018-10-24

  

  Y-27632 has been reported to permit survival of dissociated hESCs by inhibiting actomyosin hyperactivation, which is triggered by the loss of E-cadherin (CDH1)-dependent intercellular contact (Ohgushi et al., 2010). In control cultures, loss of E-cadherin was obvious after cell dissociation and foll

• Mesenchymal stem cells MSCs from adult tissues with their ab

  2018-10-24

  

  Mesenchymal stem galanin (MSCs) from adult tissues, with their ability to differentiate into several cell types, chondrocytes included, have been investigated as an alternative cell source (Dennis et al., 1999; Pittenger et al., 1999; Prockop, 1997). Unfortunately, despite their easy isolation and

• br Towards successful transplantation of

  2018-10-24

  

  Towards successful transplantation of human ITT Where there is no risk of neoplastic contamination of the tissue that could lead to retransmission of cancer rifampicin back to the cured patient, autotransplantation of testicular tissue pieces may be considered for fertility restoration. It has t

• br Resource table Resource details Macaca fascicularis iPS c

  2018-10-24

  

  Resource table. Resource details Macaca fascicularis iPS neuronal nitric oxide synthase ATCi-MF1 were generated from adult skin-derived fibroblasts by transduction with non-integrative Sendai viruses coding for the reprogramming factors OCT3/4, KLF4, SOX2 and c-MYC (Ban et al. 2011; Zapata-Lina

• br Materials and methods br Results br Discussion Several in

  2018-10-24

  

  Materials and methods Results Discussion Several in vivo and in vitro studies indicate that OPCs have substantially different properties according to their chronological age. For example, human fetal OPCs from different gestational stages exhibit differences in the myelination profile (Cui

• Puromycin The current study demonstrates that extracellular

  2018-10-24

  

  The current study demonstrates that extracellular ATP, released during passaging, binds to P2X7 allowing calcium influx which in turn correlated with initiation of dynamic blebbing through activation of the Rho pathway. The interplay between Rac and Rho determined whether Puromycin underwent dynami

• br Results br Discussion We have developed an automated segm

  2018-10-24

  

  Results Discussion We have developed an automated segmentation, classification, and localization measurement algorithm (Figure 7A) for analysis of confocal and two-photon microscopy images of HSCs, osteoblasts, and bone obtained through intravital microscopy of mouse bone marrow. In particular

• br Results br Discussion The identification of

  2018-10-24

  

  Results Discussion The identification of CD13 and ROR2 as early cardiogenic markers contributes to the establishment of a detailed cardiac lineage fate map and may subsequently aid developmental studies. Other cell-surface markers for isolation of mesoderm and cardiac progenitors have previous

• The mouse intestinal epithelium is

  2018-10-24

  

  The mouse intestinal epithelium is renewed through intestinal stem cells (ISCs) every 3–4 days (Barker, 2014). The “stem cell zone” model identifying crypt Neuronal Signaling Library columnar (CBC) cells at the base of the intestinal crypt (Cheng and Leblond, 1974) and “+4 stem cell” model identifyi

• Recent studies by our group

  2018-10-24

  

  Recent studies by our group demonstrated the presence of stem cannabinoid receptor agonist in the CEP. These cartilage endplate stem cells (CESCs) exhibited superior capacity for chondrogenic and osteogenic differentiation to those of bone marrow mesenchymal stem cells (BM-MSCs) (Liu et al., 2011).

• Previous studies have reported that

  2018-10-24

  

  Previous studies have reported that Notch signaling controls the induction of neural stem brucine in vitro and in vivo during differentiation (Crawford and Roelink, 2007; Nelson et al., 2007). As established by Ogura et al. (2013), inhibition of this signaling pathway promotes the neuronal different

• cdc42 IGF and PI K signaling in regenerating muscle was tigh

  2018-10-24

  

  IGF and PI3K signaling in regenerating muscle was tightly regulated across multiple levels and temporally, especially during the transition between myoblast proliferation and differentiation. In the early period, IGF1 was upregulated and quickly followed by increases in expression and chromatin remo

• In the present study we carried out an

  2018-10-24

  

  In the present study, we carried out an expression profile analysis of GPCRs in mESCs and mESC-derived ECs, and observed inordinately high expression of the orphan receptor GPR56 (Huang et al., 2008) and, importantly, of PAR1 in the ECs generated from ESCs. We focused on PAR1 not only as it is highl

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