• These conclusions complement the work by Nguyen and colleagu

  2018-11-09

  

  These conclusions complement the work by Nguyen and colleagues recently published in EBioMedicine, in which the authors described pathological examination conducted on 3 aborted fetuses with CRS acquired during the 2011–2012 rubella epidemic in Vietnam (). In this second observation, ocular lesions

• Having confirmed that the Nanog iPSCs expressed

  2018-11-08

  

  Having confirmed that the Nanog−/− iPSCs expressed key markers of pluripotency, we sought to determine the extent to which the global expression profile of Nanog−/− iPSCs recapitulated that of ESCs. To this end, we performed RNA sequencing (RNA-seq) of two replicates each of control Nanog+/+ ESC, iP

• br Conclusions and future perspectives Due to

  2018-11-08

  

  Conclusions and future perspectives Due to the extraordinary speed that stem cell research is proceeding, scientists rarely have time to improve or replace assay systems that are working. For industrial and clinical applications the differentiation potential assessed by in vitro differentiation w

• Besides the production of transgenic spermatozoa and animal

  2018-11-08

  

  Besides the production of transgenic spermatozoa and animal production, studies using in vitro maintained spermatogonial stem dihydrochloride are important to identify the mechanism of spermatogenesis in mammals, facilitate research on male infertility, and disseminate the genetics of animal produc

• The level of TMSB X expression

  2018-11-08

  

  The level of TMSB4X expression in the transfected HaCaT fgfr inhibitor was approximately 1.5- to 3-fold of that observed in the control HaCaT cells. TMSB4X transfection in this study did not dramatically increase TMSB4X expression in HaCaT cells. However, as shown in Fig. 4, the increased TMSB4X ex

• br Acknowledgments br This work was supported by grants from

  2018-11-08

  

  Acknowledgments This work was supported by grants from the Juvenile Diabetes Research Foundation, Stanford Medical School Child Health Research Institute funded by the Stanford NIH/NCRR CTSA award number UL1 RR025744 and by the Lucile Packard Foundation for Children\'s Health (to NW), Arthritis

• Despite published evidence that this prevalent

  2018-11-08

  

  Despite published evidence that this prevalent view was incorrect (Beltrami et al., 2001; Quaini et al., 2002; Urbanek et al., 2003; Urbanek et al., 2005; Anversa et al., 2002; Nadal-Ginard et al., 2003), it took the publication of Bergmann et al., 2009, to produce a significant switch in the preval

• tranylcypromine br Hippo Yap signaling pathway in cardiac hy

  2018-11-08

  

  Hippo/Yap signaling pathway in cardiac hypertrophy and apoptosis Adult mammalian cardiomyocytes have limited proliferative capacity, and thus increased size of the adult heart with exercise or disease is caused mainly by cardiomyocyte hypertrophy. In adult heart, the functions of the Hippo pathwa

• In demyelinating diseases injury of myelin

  2018-11-08

  

  In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as

• br Materials and methods The

  2018-11-08

  

  Materials and methods The PQ embryos from in vitro fertilization were donated, and the fetal membranes were collected in accord with the INPER Ethics Committee (212250-21071) as well as the Guidelines for the Conduct of hESC Research (ISSCR, 2006). The hAEC were isolated and cultured from human

• br Electromagnetic field resonance and signal transduction T

  2018-11-08

  

  Electromagnetic field resonance and signal transduction The application of EMF signals appears to be more than a new tool in biophysics and information medicine. It uses the basic science of physics, which drives the chemistry and the biology, to effect a biological change. Low-frequency EMF is b

• br Materials and methods br Verification and authentication

  2018-11-08

  

  Materials and methods Verification and authentication Karyotyping was performed at the Center for Applied Human Molecular Genetics, Kennedy Center, Glostrup, Denmark. At least 10 metaphases were analysed per sample with an approximate resolution of 550 to 600 bands per haploid genome. The resu

• Recent reports have indicated the functional significance

  2018-11-08

  

  Recent reports have indicated the functional significance of FOXM1 in pluripotent cells. FOXM1 is required for the maintenance of pluripotency in mouse embryonal carcinoma (EC) cells, via direct regulation of Oct4 transcription (Xie et al., 2010). More importantly, FOXM1 is important for maintaining

• The original XO karyotype Fig of

  2018-11-08

  

  The original 45 XO karyotype (Fig. 1) of the donor CVCs was maintained in TS ViPSCs even after prolonged maintenance (passage 25) indicating that the process of reprogramming with episomal vectors and in vitro culture conditions did not alter this iPSC line chromosomally. The iPSC line established i

• Our studies show that only a subpopulation of hESCs at

  2018-11-08

  

  Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that gsk3 inhibitor in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco et al., 20

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