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muscle metabolism br Experimental Procedures br Acknowledgme
2018-10-22
Experimental Procedures Acknowledgments The authors thank Uri Ben-david, Yonatan Stelzer, Daniel Ronen, Tomer Halevy, and Uri Weissbein for critically reading this manuscript and Tamar Golan-Lev for her assistance with the graphical design of the figures. We thank Yonatan Stelzer for his assis
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How ABR participates in the control of
2018-10-22
How ABR participates in the control of mitotic fidelity remains an open question. Taking into consideration that ABR action is correlated with a cellular adhesive state, the present study suggests an unrecognized link between cell-cell contact and mitotic fidelity. In general, most types of non-tran
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The gold standard for determining efficient
2018-10-22
The gold standard for determining efficient HSPC homing to bone marrow niches is their subsequent hematological reconstitution following transplantation in humans (Dahlberg et al., 2011; Ramirez et al., 2012), or, as surrogates, in immunodeficient mice or non-human primates (Goessling et al., 2011;
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Introduction Mechanical loading of cells and tissues by grav
2018-10-20
Introduction Mechanical loading of carboxypeptidase and tissues by gravity-generated forces has broad effects on mammalian cell and tissue physiology, such as in promoting the normal function and regeneration of bone, muscle, blood, and other tissues. In a healthy organism, many cell types, includ
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SBI-0206965 The effect of Sav or Lats inactivation on adult
2018-10-20
The effect of Sav1 or Lats1/2 inactivation on adult cardiomyocyte proliferation has also been examined. Inactivation of these Hippo pathway components in the adult heart increased cardiomyocyte DNA synthesis and karyokinesis (Heallen et al., 2013). Qualitatively, the result was similar to what was
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stavudine We chose to use the human GFAABC D promoter
2018-10-20
We chose to use the human GFAABC1D promoter to drive TagRFP in human astrocytes because of its accuracy to specifically direct reporter expression in astrocytes in several CNS regions, at embryonic and adult stage, in rodent (Lee et al., 2008). Interestingly, during the pre-screening stage, at 70 DI
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The catenindependent Wnt signaling pathway is also important
2018-10-20
The β-catenindependent Wnt signaling pathway is also important in the modulation of cell proliferation, cell survival, and embryo development [74–76] and is also identified as a regulator of stem cell fate determination [77,78]. It was found that phosphorylation levels of c-Myc and β-catenin (target
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hCNS SCns migration was extensive
2018-10-20
hCNS-SCns hsp90 inhibitors was extensive, detected by 1 week following transplantation, and altered by the injured microenvironment. Injury induced transplanted hCNS-SCns to remain closer to the SCI epicenter, which has been reported in other cases of CNS trauma and degeneration (Connor et al., 201
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Interestingly our transplantation study revealed
2018-10-20
Interestingly, our transplantation study revealed that Bbc3 depletion could not protect SSCs, suggesting that the Sennoside A that survived irradiation were spermatogonia progenitors. Bbc3-depleted cells retained their proliferative activity but lost their recolonizing ability. This result was unex
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azilsartan medoxomil Our data hint at a previously unrecogni
2018-10-20
Our data hint at a previously unrecognized relationship between postnatal foreskin-derived Schwann and perivascular cells, as deduced from their strikingly similar gene-expression profiles. Alternatively, the two cell subtypes might reflect a single, highly dynamic cell precursor with environmental
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baicalein Many cellular mechanisms have the potential to con
2018-10-20
Many cellular mechanisms have the potential to contribute to enlarged baicalein size and to faulty connections among centers in the brain that are thought to be linked to abnormal behaviors in ASD. While neurite outgrowth and pruning normally occur during the time period in which the accelerated bra
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Our data also provide information on the pathophysiology of
2018-10-20
Our data also provide information on the pathophysiology of FA itself. First, we found that the drastic acceleration of cell cycling observed in Fancd2 HSPCs is unique to this blood cell population. No IWR-1-endo abnormalities were observed in mature hematopoietic lineages. Others have found that t
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br Results br Discussion br Experimental
2018-10-20
Results Discussion Experimental Procedures Acknowledgments Introduction Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Hematopoietic in vitro differentiation of pluripotent stem hif inhibitor (PSCs) such as embryonic ste
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br Materials and methods br Acknowledgments This work was
2018-10-20
Materials and methods Acknowledgments This work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (grant numbers SAF2013-43005-R and SAF2016-76004-R). The authors thank INDEPF (Instituto de investigación y desarrollo social de enfermedades
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Introduction Glioblastoma multiforme GBM is
2018-10-20
Introduction Glioblastoma multiforme (GBM) is the most common adult primary amphetamine sulfate tumor, with an extremely dismal prognosis and high rate of recurrence following standard therapy (Wen and Kesari, 2008). Populations of brain tumor initiating cells (BTICs), which express many of the pro
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