• br Experimental and simulation section

  2024-03-06

  

  Experimental and simulation section Acknowledgments Financial support for this work was provided by the National Natural Science Foundation of China (No. 81101688). We would like to thank NC State University High Performance Computing Center for providing us computing resources, and Dr. Lihui

• Recently competitive inhibitors of arginase have been develo

  2024-03-06

  

  Recently, competitive inhibitors of arginase have been developed which have greater specificity for the enzyme. Initial development of these compounds involved determination of the crystal structure of arginase. Christianson and colleagues found that a binuclear manganese cluster was required for ca

• The approach of enzymatically converting an

  2024-03-06

  

  The approach of enzymatically converting an analyte and detecting it by the resulting small pH changes near the reduced graphene oxide (rGO) surface has successfully been pursued in case of urea (Piccinini et al., 2017). Furthermore, this work reported that electrostatic layer-by-layer (LbL) assembl

• Although many factors influence the effects of medications d

  2024-03-06

  

  Although many factors influence the effects of medications, during recent years it has become evident that genetic factors could explain the differences between individuals in drug response. These differences are due to variants in genes encoding drug targets [8]. The challenge for pharmacogenetics

• br Experimental methods br Acknowledgments br Introduction L

  2024-03-06

  

  Experimental methods Acknowledgments Introduction Long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses are thought to underlie experience-dependent learning and memory. These synaptic plasticity mechanisms are best characterized at hippocampal CA1 synapses, whe

• Histochemical analyses using antibody or cDNA probes

  2024-03-06

  

  Histochemical analyses using antibody or cDNA probes reveal the precise cellular location of the 12S-lipoxygenases in tissues of interest. An immunohistochemical study in various rat tissues showed specific expression of the leukocyte-type 12S-lipoxygenase in macrophages in lung and spleen [27]. In

• br Current therapies for metabolic diseases Inborn

  2024-03-06

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

• In a recent series of studies

  2024-03-06

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat Proteinase K mg wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induce

• A more versatile cellular delivery system for adenosine was

  2024-03-06

  

  A more versatile cellular delivery system for adenosine was generated by engineering mouse embryonic stem cells to lack both NT157 of Adk (Fedele et al., 2004). Using a step-wise differentiation protocol (Okabe et al., 1996) Adk−/− ES cells were differentiated into transplantable adenosine-releasing

• The pathogenesis of d penicillamine induced MG is

  2024-03-06

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR Spadin in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-penici

• In most industrial areas which are in

  2024-03-05

  

  In most industrial areas which are in need of treatment, there are mixtures of different contaminants at different concentrations in soil, underground water or wastewater. These hazardous wastes include a variety of salts, organic matter, heavy metals, trace elements and radioactive compounds [5].Si

• br Conclusion In this brief Letter we report an

  2024-03-05

  

  Conclusion In this brief Letter, we report an easy method for the preparation of the antileukemic natural product 1. Using a biomimetic strategy,1, 8 in which the aromatic residues are attached to a lysine moiety prior to the reduction of the central carboxylate group, a step-economical synthesis

• br Antibiotic drug discovery approaches Traditionally novel

  2024-02-23

  

  Antibiotic drug discovery approaches Traditionally, novel BI-1356 were largely discovered by phenotypic screening approaches of various sources of compounds, such as natural products isolated from extracts of soil microbes and semi-synthetic or fully synthetic compound libraries derived from kno

• Animal fat appears to increase C

  2024-02-23

  

  Animal fat appears to increase C. perfringens counts compared with vegetable oil, so there may indeed be some advantage to vegetable diets at least in terms of fat sources (Knarreborg et al., 2002). Small grains such as wheat, rye, oats, and barley, with high levels of non-starch polysaccharides are

• Angiogenesis is a process of formation of new vessels

  2024-02-23

  

  Angiogenesis is a process of formation of new vessels from arterial vascularization created by endothelial cells. It is essential for the continuous growth of the tumor because it supplies the tumor with nutrients and oxygen, and eliminates cellular waste, which can be toxic to cancer cells [8]. Inf

15923 records 181/1062 page Previous Next First page 上5页 181182183184185 下5页 Last page